Preferred Label : Anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes;
NCIt synonyms : EGFR-IL12-CAR T-cells;
NCIt definition : A preparation of human T-lymphocytes transduced with a retroviral vector encoding
an anti-epidermal growth factor receptor (EGFR) chimeric antigen receptor (CAR) gene
coupled to the signaling domains from CD28, 4-1BB (CD137) and CD3 zeta, and modified
to express the cytokine interleukin-12 (IL-12), with potential immunostimulatory and
antineoplastic activities. Upon administration, the anti-EGFR CAR-transduced IL-12-expressing
T-lymphocytes target and bind to the EGFR antigen on tumor cell surfaces; subsequently,
EGFR-expressing tumor cells may be lysed. IL-12 expression activates the immune system
by promoting the secretion of interferon-gamma (IFNg), activating natural killer cells
(NKs), and inducing cytotoxic T-cell responses, which may result in both decreased
cell proliferation and increased cell death for the EGFR-overexpressing tumor cells.
EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell
proliferation, tumor angiogenesis and radio- and chemoresistance.;
NCI Metathesaurus CUI : CL938079;
Origin ID : C158602;
UMLS CUI : C4764288;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
