Proteasome Adapter and Scaffold Protein ECM29

Preferred Label : Proteasome Adapter and Scaffold Protein ECM29;

NCIt synonyms : Ecm29 Proteasome Adapter and Scaffold; Proteasome-Associated Protein ECM29 Homolog; Ecm29 Proteasome Adaptor and Scaffold; ECPAS;

NCIt definition : Proteasome adapter and scaffold protein ECM29 (1845 aa, 204 kDa) is encoded by the human ECPAS gene. This protein plays a role in proteasome localization and assembly.;

NCIt note : Variation in the proteasome adapter and scaffold protein ECM29 may be associated with breast cancer as a patient with chemorefractory hormone receptor (HR)-positive metastatic breast cancer had complete regression of the cancer for over 22 months after treatment with tumor-infiltrating lymphocytes (TILs) that targeted mutant forms of this and three other proteins that were expressed in the patient's tumor in conjunction with aldesleukin and pembrolizumab. (Nature Medicine 2018; 24:724-730);

NCI Metathesaurus CUI : CL937983;

Details

Origin ID

C158580;

UMLS CUI

C4761523;

Automatic exact mappings (from CISMeF team)
- Ecm29 proteasome adaptor and scaffold [HGNC gene]
- Ecm29 proteasome adaptor and scaffold protein [OMIM gene]
OMIM relation
- Ecm29 proteasome adaptor and scaffold protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
gene_encodes_gene_product
- ECPAS Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_biochemical_function
- Scaffolding Protein [NCIt concept]

Keyword's position in hierarchy(ies) :

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