Preferred Label : Autologous CMV-pp65-shLAMP-1 mRNA Loaded Dendritic Cell Vaccine;
NCIt synonyms : pp65-shLAMP-1 mRNA DCs; Autologous shLAMP-1-pp65-DC Vaccine; Autologous shLAMP-1-pp65-DCs; Autologous pp65-shLAMP-1 DC Vaccine; Autologous shLAMP-1-pp65 mRNA-pulsed DC Vaccine;
NCIt definition : A cancer cell vaccine consisting of autologous dendritic cells pulsed with mRNA encoding
the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein;
UL83) as a fusion construct with a short peptide chimeric antigen from lysosome-associated
membrane protein 1 (shLAMP-1), with potential antineoplastic and immunostimulatory
activities. Upon vaccination, the autologous CMV-pp65-shLAMP-1 vaccine exposes the
immune system to the CMV pp65 peptide, which may elicit a cytotoxic T-lymphocyte (CTL)
response against CMV pp65-expressing tumor cells. The incorporation of shLAMP-1 may
route CMV pp-65 antigens into the lysosomal compartment, resulting in enhanced MHC
class II antigen presentation, thereby promoting CD4-positive T-cell responses. The
CMV pp65 protein is the primary component of the enveloped sub-viral particle of CMV
and is expressed in certain tumor types.;
NCI Metathesaurus CUI : CL937978;
Origin ID : C158522;
UMLS CUI : C4764269;
Semantic type(s)
- concept_is_in_subset
- has_target
