Preferred Label : Technetium Tc-99m Anti-HER2 Affibody ABH2;
NCIt synonyms : 99mTc-ABH2; HER2-targeting 99mTc-labeled Affibody;
NCIt definition : A radioconjugate composed of an optimized affibody labeled with technetium Tc 99m,
with potential use as a tracer for human epidermal growth factor receptor type 2 (HER2;
ErbB2)-expressing tumors using single photon emission computed tomography (SPECT).
Upon administration, the Tc 99m-labeled affibody ABH2 targets and binds to HER2-expressing
tumor cells. This facilitates both detection of HER2-expressing tumor cells and assessment
of responses to HER2-targeting chemotherapeutic agents using SPECT. HER2, a receptor
tyrosine kinase, is mutated in many tumor cell types and plays a key role in tumor
cell proliferation and tumor vascularization.;
NCI Metathesaurus CUI : CL938050;
Origin ID : C158509;
UMLS CUI : C4764261;
Semantic type(s)
- concept_is_in_subset
