Preferred Label : Linperlisib;
NCIt synonyms : PI3K-delta Inhibitor YY-20394;
NCIt definition : An orally available selective inhibitor of the delta form of phosphatidylinositol
3-kinase (PI3-kinase subunit delta; PI3K-delta; PI3Kdelta), with potential antineoplastic
activity. Upon oral administration linperlisib selectively binds to and inhibits PI3K-delta
and prevents the activation of the PI3K/AKT signaling pathway. This decreases proliferation
of and induces cell death in PI3K-delta over-expressing tumor cells. PI3K-delta also
plays a key role in the B-cell receptor (BCR) signaling pathway and the proliferation
of certain hematologic cancer cells. The targeted inhibition of PI3K-delta is designed
to preserve PI3K signaling in normal, non-neoplastic cells, thereby minimizing serious
side effects.;
UNII : 05HYK3CV9N;
InChIKey : NVWKNQGHVMMAJW-UHFFFAOYSA-N;
CAS number : 1702816-75-8;
Molecule name : YY 20394; YY-20394;
NCI Metathesaurus CUI : CL938053;
Origin ID : C158508;
UMLS CUI : C5418267;
Semantic type(s)
- concept_is_in_subset
- has_target
