Preferred Label : Obefazimod;
NCIt synonyms : CBC 80/20 Binder ABX-464; 8-Chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine; Rev Inhibitor ABX-464; Cap Binding Complex 80/20 Binder ABX-464; ABX 464;
NCIt definition : An orally available, small molecule binder of the cap binding complex (CBC) 80/20,
with potential antiviral and anti-inflammatory activities. Upon oral administration,
obefazimod binds to the CBC, a complex at the 5'-end of the pre-mRNA transcript that
promotes the initial interaction with transcription and processing machinery. This
leads to a conformational change in the CBC and enhanced splicing of viral RNA variants
and upregulation of the anti-inflammatory microRNA, miR-124, via splicing of a long
noncoding RNA at the miR-124-1 locus. In human immunodeficiency virus type 1 (HIV-1)-infected
cells, obefazimod interacts with the CBC of HIV-1 mRNA and inhibits viral replication
by preventing Rev-mediated export of unspliced HIV-1 transcripts to the cytoplasm.
Rev facilitates the nuclear export of unspliced or incompletely spliced viral pre-mRNAs,
an essential step in HIV-1 replication. In inflammatory conditions, miR-124 reduces
the production of various inflammatory mediators, including interleukin 6 (IL-6),
tumor necrosis factor alpha (TNF-alpha), and C-C motif chemokine 2 (CCL2; MCP-1.).
miR-124 plays a critical role in innate and adaptive immune responses and is a critical
mediator of cholinergic anti-inflammatory action.;
UNII : 26RU378B9V;
CAS number : 1258453-75-6;
Molecule name : ABX-464; SPL-464;
NCI Metathesaurus CUI : CL938055;
Origin ID : C158506;
UMLS CUI : C5667183;
Currated CISMeF NLP mapping
- ABX464 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- ABX464 [MeSH Supplementary Concept]
- concept_is_in_subset
