" /> Linvoseltamab - CISMeF





Preferred Label : Linvoseltamab;

NCIt synonyms : BiTE Antibody REGN5458; Anti-BCMA x Anti-CD3 BiTE REGN5458; Bispecific BCMA x CD3 T-cell Engaging Antibody REGN5458; Anti-BCMA/CD3 BiTE Antibody REGN5458;

NCIt definition : A human bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFvs): one directed again the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and another directed against the CD3 antigen expressed on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, linvoseltamab binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, leading to CTL-mediated killing of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival.;

UNII : M3CPC50MZS;

CAS number : 2408319-25-3;

Molecule name : REGN 5458; REGN-5458;

NCI Metathesaurus CUI : CL938057;

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08/05/2025


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