NCIt definition : A human bispecific T-cell engager (BiTE) antibody composed of two single-chain variable
fragments (scFvs): one directed again the tumor-associated antigen (TAA) human B-cell
maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17)
and another directed against the CD3 antigen expressed on T-lymphocytes, with potential
immunostimulating and antineoplastic activities. Upon administration, linvoseltamab
binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA on BCMA-expressing tumor
cells. This activates and redirects CTLs to BCMA-expressing tumor cells, leading to
CTL-mediated killing of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis
factor receptor superfamily that is specifically overexpressed on malignant plasma
cells, plays a key role in promoting plasma cell survival.;
Semantic type(s)