Preferred Label : iPSC-derived Natural Killer Cells FT500;
NCIt synonyms : iPSC-derived NK Cells FT500; Induced Pluripotent Stem Cell-derived Natural Killer Cells FT500; iPSC-NK Cells FT500;
NCIt definition : A preparation of off-the-shelf, natural killer (NK) cells derived from a clonal master
induced pluripotent stem cell (iPSC) line, with potential antineoplastic and immunostimulatory
activities. Upon administration, iPSC-derived natural killer cells FT500 bind to stress-induced
ligands on tumor cells, leading to tumor cell lysis and release of tumor neoantigens.
Additionally, iPSC-NK cells secrete inflammatory cytokines and chemokines including
interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), C-C motif chemokines
3, 4, and 22 (CCL3, CCL4, and CCL22), and C-X-C motif chemokine 10 (CXCL10), thereby
enhancing T-cell activity and recruitment to the tumor site.;
Molecule name : FT 500; FT-500;
NCI Metathesaurus CUI : CL937880;
Origin ID : C158438;
UMLS CUI : C4764367;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
