Fibronectin Type III Domain-Containing Protein 5

Preferred Label : Fibronectin Type III Domain-Containing Protein 5;

NCIt synonyms : Fibronectin Type III Domain Containing Protein 5; FNDC5; Fibronectin Type III Repeat-Containing Protein 2;

NCIt definition : Fibronectin type III domain-containing protein 5 (212 aa, 24 kDa) is encoded by the human FNDC5 gene. This protein plays a role in the cellular response to physical reactivity.;

NCIt note : Following removal of the signal peptide, fibronectin type III domain-containing protein 5 is cleaved C-terminally after amino acid residue 143, which removes the transmembrane microbody targeting signal, yielding the secreted protein irisin. (UniProt);

NCI Metathesaurus CUI : CL937842;

Details

Origin ID

C158412;

UMLS CUI

C4761705;

Automatic exact mappings (from CISMeF team)
- Fibronectin type III domain-containing protein 5 [OMIM gene]
OMIM relation
- Fibronectin type III domain-containing protein 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- FNDC5 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Peroxisome [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
is_target
- Anti-AGS-8 Monoclonal Antibody AGS-8M4 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients