Preferred Label : Anti-CD38/BCMA CAR T-lymphocytes;
NCIt synonyms : Anti-CD38/Anti-BCMA CAR T-cells; Anti-CD38/Anti-BCMA CAR T-lymphocytes; Anti-CD38/BCMA CAR T-cells;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a dual-targeted
chimeric antigen receptor (CAR) recognizing the tumor-associated antigens (TAAs),
cluster of differentiation 38 (CD38) and B-cell maturation antigen (BCMA; tumor necrosis
factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating
and antineoplastic activities. Upon intravenous administration, the anti-CD38/BCMA
CAR T-cells are directed to and induce selective toxicity in both CD38- and BCMA-expressing
cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells
and hematologic malignancies, and its expression has been correlated with poor prognosis.
BCMA is found on the surfaces of plasma cells and is and overexpressed on malignant
plasma cells.;
NCI Metathesaurus CUI : CL937692;
Origin ID : C158087;
UMLS CUI : C4764038;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
