Pimodivir - CISMeF

Preferred Label : Pimodivir;

NCIt definition : An orally bioavailable non-nucleoside inhibitor of the polymerase basic protein 2 (PB2) subunit of the influenza A virus polymerase complex with potential antiviral activity. Upon administration, pimodivir occupies the 7-methyl GTP (m7GTP) binding site of PB2, thereby blocking the cap-snatching activity of the influenza polymerase complex and inhibiting the synthesis of viral mRNA. PB2 is one of three subunits that make up the influenza A viral polymerase complex, which is responsible for replication and transcription of the viral RNA (vRNA) genome in the nuclei of infected cells.;

UNII : DFC121MXC3;

InChIKey : JGPXDNKSIXAZEQ-SBBZOCNPSA-N;

CAS number : 1629869-44-8;

Molecule name : VX-787; JNJ 63623872; VX 787; JNJ-63623872;

NCI Metathesaurus CUI : CL937691;

Details

Origin ID

C158086;

UMLS CUI

C4764037;

Currated CISMeF NLP mapping
- pimodivir [MeSH Supplementary Concept]
- pimodivir [MeSH concept]
Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- pimodivir [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients