Preferred Label : Super Enhancer Inhibitor GZ17-6.02;
NCIt synonyms : Synthetic Arum palaestinum derivative GZ17-6.02;
NCIt definition : A synthetic formulation of the Arum palaestinum plant that has been fortified with
the already naturally occurring constituents of isovanillin, linolenic acid, and beta-sitosterol,
with potential antineoplastic activity. Upon oral administration, GZ17-6.02 may induce
apoptosis through caspase-3 activation and poly(ADP-ribose) polymerase (PARP) cleavage,
inhibit tumor cell progression by attenuating macrophage infiltration, and inhibit
the phosphorylation of several mediators of tumor cell proliferation including Src
kinase, extracellular signal-regulated kinases 1 (ERK1) and 2 (ERK2), epidermal growth
factor receptor (EGFR), serine/threonine protein kinase AKT (protein kinase B), signal
transducer and activator of transcription 2 (STAT-2), and serine/threonine-protein
kinase Chk2 (Chk-2). GZ17-6.02 may also inhibit certain super enhancers (SEs) that
play an important role in the regulation of the sonic hedgehog (SHH) pathway and cancer
stem cell activity. Super enhancers (SEs) are unique areas of the genome that are
densely bound by numerous transcription factors and play a pivotal role in the cell,
including tissue specification, identity and maintenance. SEs are known to regulate
the expression of associated genes and often drive high-level transcription.;
Molecule name : GZ17-6.02; GZ17 6.02;
NCI Metathesaurus CUI : CL937695;
Origin ID : C158082;
UMLS CUI : C4764033;
Semantic type(s)
- concept_is_in_subset
