" /> Nicotinamide Riboside - CISMeF





Preferred Label : Nicotinamide Riboside;

NCIt synonyms : NR;

NCIt definition : An orally available form of vitamin B3 and precursor of nicotinamide adenine dinucleotide (NAD ) with potential use in the treatment of chemotherapy induced peripheral neuropathy (CIPN). Upon oral administration, nicotinamide riboside (NR) is converted to nicotinamide mononucleotide by the NR kinases, nicotinamide riboside kinase 1 (NRK 1) and nicotinamide riboside kinase 2 (NRK 2), to which a second adenine is transferred by nicotinamide mononucleotide adenylyl transferase to generate NAD . NAD , an essential redox coenzyme, may offer protective effects against axonal injury from both mechanical and neurotoxic injury, and maintenance of NAD may be protective in mitochondrial disease. NR may help elevate and maintain NAD levels, which may ameliorate potential mechanisms implicated in the development of CIPN including mitochondrial dysfunction and peripheral nerve degeneration.;

UNII : 0I8H2M0L7N;

CAS number : 1341-23-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1341-23-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Niagen;

NCI Metathesaurus CUI : CL937699;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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