Preferred Label : Vusolimogene Oderparepvec;
NCIt synonyms : Genetically Modified HSV-1 Oncolytic Immunotherapeutic RP1; HSV-1 Engineered RP1; Oncolytic Virus RP1; HSV-1 Oncolytic Viral Strain RP1; HSV-1 RP1;
NCIt definition : A genetically modified oncolytic viral strain of the herpes simplex type 1 (HSV-1)
virus, with potential oncolytic, immunostimulating and antineoplastic activities.
Upon administration, vusolimogene oderparepvec specifically targets, infects and replicates
in tumor cells only while not infecting normal, healthy cells. This induces tumor
cell lysis. The released virus particles, infect and replicate in neighboring tumor
cells, thereby further killing tumor cells. The released tumor-associated antigens
(TAAs) from the tumor cells activate the immune system to exert an anti-tumor immune
response against the tumor cells, thereby further killing the tumor cells. The virus
itself also elicits a tumor-specific systemic immune and cytotoxic T-lymphocyte (CTL)
response, thereby killing nearby non-infected tumor cells. In RP1, ICP34.5 and 47
proteins of the HSV1 strain have been deleted; RP1 expresses a fusogenic protein for
optimal tumor cell infection and killing.;
UNII : 45KLN7N6UV;
CAS number : 2305659-09-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2305659-09-8
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : RP-1;
NCI Metathesaurus CUI : CL937703;
Origin ID : C158074;
UMLS CUI : C5554555;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
