" /> Bispecific Antibody MDX-H210 - CISMeF





Preferred Label : Bispecific Antibody MDX-H210;

NCIt synonyms : Bispecific Antibody 520C9 x H22; 520C9xH22 Bispecific Antibody; BsAb 520C9x22; 520C9x22 Bispecific Antibody; BsAb 520C9xH22; Antibody, Bispecific 520C9xH22; Bispecific Antibody MDXH210; Bispecific Antibody 520C9XH22;

NCIt definition : A humanized bivalent antibody directed against both cytotoxic effector cells expressing Fc gamma receptor type I (Fc gammaRI, or CD64) and HER2/neu-overexpressing tumor cells with potential antineoplastic activity. Bispecific antibody MDX-H210 was constructed by chemically linking Fab' fragments of the anti-HER2/neu-specific monoclonal antibody 520C9 and the Fab' fragments of the anti-Fc gammaRI-specific monoclonal antibody H22. This agent selectively binds to both HER2/neu-expressing tumor cells and Fc gammaRI-expressing cytotoxic effector cells, which may trigger antibody-dependent cell-mediated cytotoxicity (ADCC) and cell lysis of HER2/neu-expressing tumor cells. While HER2/neu is overexpressed in a variety of epithelial malignancies, expression of Fc gammaRI is primarily found in cytotoxic immune cells, including monocytes, macrophages, and cytokine-activated polymorphonuclear (PMN) cells.;

Molecule name : MDX-H210; MDX-210;

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15/05/2024


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