Preferred Label : Maraba Oncolytic Virus Expressing Mutant HPV E6/E7;
NCIt synonyms : Oncolytic MG1 Virus-encoding E6E7; MG1-expressing Mutant HPV E6/E7; MG1-E6E7; MG1-E6/E7; Oncolytic Virus MG1-E6E7;
NCIt definition : A cancer vaccine comprised of a recombinant, attenuated form of the oncolytic rhabdovirus
Maraba (MG1) encoding inactive, mutant forms of the human papillomavirus (HPV) transforming
proteins E6 and E7, with potential immunostimulating and antineoplastic activities.
Upon administration of MG1-E6E7, MG1 preferentially infects tumor cells and induces
the expression of the E6 and E7 proteins. The MG1 virus exerts its oncolytic activity,
thereby directly lysing tumor cells. Following the lysis of infected cells, the virus
is released and can infect adjacent cells, which both induces further tumor cell oncolysis
and may activate the immune system to kill the infected tumor cells. The expressed
E6 and E7 proteins stimulate the host immune system to mount a cytotoxic T-lymphocyte
(CTL) response against tumor cells expressing HPV E6 and E7, thereby further inducing
tumor cell lysis. Oncoproteins E6 and E7 play a key role in the development of cervical
intraepithelial neoplasia (CIN) and cervical carcinoma.;
NCI Metathesaurus CUI : CL937424;
Origin ID : C157776;
UMLS CUI : C4763847;
Semantic type(s)
- concept_is_in_subset
- has_target
