Preferred Label : Cavrotolimod;
NCIt synonyms : Toll-like Receptor 9 Activator AST-008; SNA AST-008; TLR9 Agonist AST-008;
NCIt definition : A spherical nucleic acid (SN)-based agonist of toll-like receptor 9 (TLR9), with potential
immunostimulating activity. Upon administration, cavrotolimod targets and is able
to enter various immune cells, including monocytes/macrophages, plasmacytoid dendritic
cells (pDCs), natural killer (NK) cells and B cells, through endocytosis. Within the
endosome, it binds to and activates TLR9. TLR9 activation induces immune signaling
pathways and activates various immune cells, including B-cells, pDCs, NKs, and induces
both the production of T-helper 1 cells (Th1) and a Th1-mediated immune response as
well as a cytotoxic T-lymphocyte (CTL)-based immune response against tumor cells.
This results in an inhibition of tumor cell proliferation. TLR9 is a member of the
TLR family, which plays a fundamental role in pathogen recognition and activation
of innate and adaptive immune responses. The SNA is a dense, radial arrangement of
nucleic acids (DNA) on the surface of liposomal nanoparticles, providing a 3D-construct,
that has a high cellular uptake and an increased presentation of the DNA for TLR9
agonism. It also protects against breakdown by nucleases and increases the half-life
of the construct compared to linear oligonucleotides that are not in SNA format.;
UNII : 2Z5JOV1PPN;
CAS number : 2378664-12-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2378664-12-9
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : AST-008; AST 008;
NCI Metathesaurus CUI : CL937384;
Origin ID : C157771;
UMLS CUI : C5446338;
Semantic type(s)
- concept_is_in_subset
- has_target
