Preferred Label : Expanded/Activated Gamma Delta T-cells;
NCIt synonyms : EAGD T-cells; EAGD T-lymphocytes; Expanded and Activated Gamma Delta T-cells; Expanded and Activated Gamma/Delta T-cells;
NCIt definition : A preparation of gamma delta T-lymphocytes derived from donor T-cells that have been
expanded and activated ex-vivo and further depleted of alpha and beta T-cell receptors
(TCRs), with potential immunomodulating and antineoplastic activities. Upon administration,
these expanded/activated gamma delta (EAGD) T-cells secrete interferon-gamma (IFN-g)
and exert direct killing of tumor cells. In addition, these cells activate the immune
system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma
delta T-lymphocytes play a key role in the activation of the immune system and do
not require major histocompatibility complex (MHC)-mediated antigen presentation to
exert their cytotoxic effect.;
NCI Metathesaurus CUI : CL937176;
Origin ID : C157634;
UMLS CUI : C4763759;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
