Preferred Label : Neoantigen-encoding Personalized Virus-2;
NCIt synonyms : PSV2; PSV-2;
NCIt definition : A personalized cancer vaccine comprised of a not yet disclosed oncolytic virus encoding
tumor-specific neoantigens that have been identified through genetic sequencing of
a patient's tumor cells, with potential immunostimulatory and antineoplastic activities.
Upon administration, the neoantigen-encoding personalized virus-2 (PSV-2) infects
cells and expresses the tumor-specific neoantigens (TSNAs). This stimulates the host
immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells
expressing the TSNAs, leading to tumor cell lysis.;
NCI Metathesaurus CUI : CL937175;
Origin ID : C157633;
UMLS CUI : C4763758;
Semantic type(s)
- concept_is_in_subset
