Preferred Label : Lutetium Lu 177 Zalsenertant Tetraxetan;
NCIt synonyms : 177Lu-3BP-227; 177Lu-IPN01087; Lutetium Lu 177 DOTA-3BP-227; 177Lu-DOTA-3BP-227; 177Lu-DOTA-IPN01087; Lutetium Lu 177 DOTA-IPN01087;
NCIt related terms : ZALSENERTANT TETRAXETAN LUTETIUM LU-177;
NCIt definition : A radioconjugate consisting of the neurotensin receptor type 1 (NTR1) antagonist,
IPN01087 (3BP-227), that is linked, via the chelating agent, dodecanetetraacetic acid
(DOTA), to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic
activity and imaging activity during positron emission tomography/computed tomography
(PET/CT). Upon administration, lutetium Lu 177 zalsenertant tetraxetan binds to NTR1
expressed on certain tumor cells. Upon binding and internalization, this radioconjugate
specifically delivers a cytotoxic dose of beta radiation to NTR1-expressing cells.
NTR1, a G-protein coupled receptor, is highly expressed in ductal pancreatic adenocarcinoma
but not in normal pancreatic tissue.;
UNII : WH9EXQ390Z;
NCI Metathesaurus CUI : CL937180;
Origin ID : C157630;
UMLS CUI : C5446337;
Semantic type(s)
- concept_is_in_subset
- has_target
