Preferred Label : Sedoxantrone Trihydrochloride;
NCIt synonyms : 2H-(1)Benzothiopyrano(4,3,2-cd)indazol-8-ol, 5-((2-aminoethyl)amino)-2-(2-(diethylamino)ethyl)-,
Trihydrochloride;
NCIt related terms : LEDOXANTRONE TRIHYDROCHLORIDE; CI-958;
NCIt definition : The trihydrochloride salt of the anthrapyrazole antineoplastic antibiotic sedoxantrone
with potential antineoplastic activity. Sedoxantrone intercalates into DNA and interacts
with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein
synthesis.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. Sedoxantrone
trihydrochloride binds to DNA and stops cells, including cancer cells, from repairing
damage to DNA and from making more DNA, RNA, and protein. It is a type of DNA intercalator.;
UNII : X9GSL37ED0;
InChIKey : RNZAEKUSZHXFMR-UHFFFAOYSA-N;
CAS number : 119221-49-7;
Molecule name : CI 958; CI-958;
Chemical formula : C21H27N5OS.3ClH;
NSC code : 635371;
Codes from synonyms : CDR0000045429; CDR0000046059;
Origin ID : C1576;
UMLS CUI : C1519223;
Semantic type(s)
- concept_is_in_subset
