Darunavir/Cobicistat

Preferred Label : Darunavir/Cobicistat;

NCIt synonyms : DRV/COBI;

NCIt related terms : Rezolsta;

NCIt definition : A fixed combination of darunavir, an inhibitor of the human immunodeficiency virus (HIV) protease; and cobicistat, a cytochrome P450 3A (CYP3A) inhibitor that may be used to treat HIV infection. Upon oral administration, darunavir binds to and inhibits the dimerization and catalytic activity of the HIV aspartyl protease. This inhibits the cleavage of HIV-encoded Gag and Gag-Pol polyproteins in virus-infected cells, which prevents the formation of mature infectious virions. Cobicistat inhibits CYP3A, thereby limiting the metabolism of darunavir and increases its systemic exposure.;

Drug name : Prezcobix; Rezolsta;

Details

Origin ID

C157536;

UMLS CUI

C3871454;

Currated CISMeF NLP mapping
- Darunavir and Cobicistat [ICD-11 Extension code]
- cobicistat mixture with darunavir [MeSH Supplementary Concept]
- cobicistat mixture with darunavir [MeSH concept]
See also inter- (CISMeF)
- Product containing cobicistat and darunavir (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing cobicistat and darunavir (medicinal product) [SNOMED CT concept]
- cobicistat mixture with darunavir [MeSH Supplementary Concept]
- darunavir and cobicistat [ATC Code]
Validated automatic mappings to BTNT
- darunavir and cobicistat [ATC Code]
concept_is_in_subset
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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