Preferred Label : Therapeutic Ex Vivo-expanded Allogeneic gamma delta T-cells TCB-202;
NCIt synonyms : Ex-vivo Expanded Allogeneic gd T-lymphocytes; Therapeutic Ex Vivo-expanded Allogeneic gamma, delta T-Cells;
NCIt related terms : TCB-202;
NCIt definition : An off-the-shelf preparation of a subset of therapeutic, ex vivo-expanded, allogeneic
T-lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs),
with potential immunomodulating and antineoplastic activities. Upon administration
of the therapeutic ex vivo-expanded allogeneic gamma delta T-cells TCB-202, these
cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In
addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte
(CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the
activation of the immune system and do not require major histocompatibility complex
(MHC)-mediated antigen presentation to exert their cytotoxic effect.;
UNII : 9B6H5Y8CA4;
Drug name : OmnImmune;
Molecule name : TCB-202; TCB 202;
NCI Metathesaurus CUI : CL937072;
Origin ID : C157487;
UMLS CUI : C4763654;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
