Preferred Label : Therapeutic Ex Vivo-expanded Allogeneic gamma delta T-cells;
NCIt synonyms : Ex-vivo Expanded Allogeneic gd T-lymphocytes; Therapeutic Ex Vivo-expanded Allogeneic gamma, delta T-Cells;
NCIt definition : An off-the-shelf preparation of a subset of therapeutic, ex vivo-expanded, allogeneic
T-lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs),
with potential immunomodulating and antineoplastic activities. Upon administration
of the therapeutic ex vivo-expanded allogeneic gamma delta T-cells, these cells secrete
interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these
cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response
against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of
the immune system and do not require major histocompatibility complex (MHC)-mediated
antigen presentation to exert their cytotoxic effect.;
Drug name : OmnImmune;
NCI Metathesaurus CUI : CL937072;
Origin ID : C157487;
UMLS CUI : C4763654;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
