Preferred Label : Fluorine F 18-Active Site Inhibited Factor VIIa;
NCIt synonyms : 18F-ASIS;
NCIt definition : A radioconjugate containing a tissue factor (TF) tracer, a derivative of activated
factor VII (FVIIa), labeled with fluorine F 18, with potential use for TF-expressing
tumor imaging using positron emission tomography (PET). Upon administration of fluorine
F 18 active site inhibited factor VIIa (18F-ASIS), the active site inhibited factor
VIIa (FVIIai) moiety selectively targets and binds, with a much higher binding affinity
than FVIIa, to TF. Upon PET imaging, tumor cells expressing TF can be visualized and
assessed. TF, a transmembrane glycoprotein, is overexpressed on certain tumor cell
types and is correlated with tumor aggression and poor prognosis.;
NCI Metathesaurus CUI : CL937078;
Origin ID : C157486;
UMLS CUI : C4763653;
Semantic type(s)
- concept_is_in_subset
