Preferred Label : Valproic Acid-Expanded Umbilical Cord Blood-derived CD34-positive Cells;
NCIt synonyms : VPA-expanded Cord Blood Stem Cells; VPA-expanded UCB Stem Cells;
NCIt definition : A preparation of umbilical cord blood (UCB)-derived CD34-positive cells treated with
valproic acid (VPA) with potential use in hematopoietic stem cell transplant (HSCT).
Upon positive immunomagnetic selection of CD34-positive cells from UCB units, CD34-positive
cells are expanded in culture with stem cell factor (SCF), FMS-like tyrosine kinase
3 ligand (Flt3L), thrombopoietin (TPO), and interleukin-3 (IL-3), treated with VPA,
and infused into the patient. VPA, a histone deacetylase inhibitor (HDACi), may induce
epigenetic changes in UCB hematopoietic stem cells (HSCs), resulting in expansion
of CD34-positive cells enriched in short term (ST), intermediate term (IT), and long
term (LT) marrow repopulating cells (RCs), which are capable of sustained hematopoietic
engraftment following transplantation. Further, VPA-expanded UCB stem cells may shorten
the time to neutrophil and platelet recovery and maintain long-term hematopoietic
and immune reconstitution compared to untreated UCB grafts.;
NCI Metathesaurus CUI : CL937163;
Origin ID : C157453;
UMLS CUI : C4763629;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
