Preferred Label : Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate;
NCIt synonyms : FTC/RPV/TDF; Emtricitabine/Rilpivirine/Tenofovir;
NCIt related terms : Eviplera;
NCIt definition : A fixed combination of emtricitabine, a nucleoside reverse transcriptase (RT) inhibitor
(NRTI) analog of cytidine; rilpivirine, a non-nucleoside RT inhibitor (NNRTI); and
tenofovir disoproxil fumarate, an NRTI analog of adenosine monophosphate, that is
used to treat human immunodeficiency virus (HIV) infection. Upon oral administration,
rilpivirine binds to HIV RT, thereby blocking RNA and DNA-dependent DNA polymerase
activities including viral replication. Emtricitabine and tenofovir disoproxil fumarate
inhibit the activity of HIV RT by competing with natural deoxyribonucleosides for
incorporation into the growing viral DNA chain resulting in early chain termination.
This interferes with the generation of DNA copies of viral RNA, which is necessary
for the synthesis of new virions.;
Drug name : Complera; Eviplera;
Origin ID : C157408;
UMLS CUI : C3244537;
CISMeF manual mappings
- Semantic type(s)
