Abacavir Sulfate/Lamivudine

Preferred Label : Abacavir Sulfate/Lamivudine;

NCIt synonyms : ABC/3TC; Abacavir/Lamivudine;

NCIt related terms : Kivexa;

NCIt definition : A fixed combination of abacavir sulfate, a nucleoside reverse transcriptase inhibitor (NRTI) analog of guanosine and lamivudine, an NRTI analog of cytidine, that is used to treat human immunodeficiency virus (HIV) infection. Upon oral administration, abacavir and lamivudine are phosphorylated into active metabolites that compete for incorporation into viral DNA. These metabolites inhibit the HIV reverse transcriptase (RT) enzyme competitively and act as a chain terminator of DNA synthesis. This interferes with the generation of DNA copies of viral RNA, which is necessary for the synthesis of new virions.;

Drug name : Epzicom; Kivexa;

Details

Origin ID

C157405;

UMLS CUI

C1613391;

Automatic exact mappings (from CISMeF team)
- Lamivudine and Abacavir [ICD-11 Extension code]
Currated CISMeF NLP mapping
- abacavir, lamivudine drug combination [MeSH Supplementary Concept]
- abacavir, lamivudine drug combination [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing abacavir and lamivudine (medicinal product) [SNOMED CT concept]
- abacavir, lamivudine drug combination [MeSH concept]
- abacavir, lamivudine drug combination [MeSH Supplementary Concept]
- lamivudine and abacavir [ATC Code]
Validated automatic mappings to BTNT
- lamivudine and abacavir [ATC Code]

Keyword's position in hierarchy(ies) :

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