Preferred Label : Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate;
NCIt synonyms : Elvitegravir/Cobicistat/ Emtricitabine/Tenofovir; EVG/COBI/FTC/TDF;
NCIt definition : A fixed combination of elvitegravir, a human immunodeficiency virus type 1 (HIV-1)
integrase strand transfer inhibitor (INSTI); cobicistat, a cytochrome P450 3A (CYP3A)
inhibitor; emtricitabine, a nucleoside reverse transcriptase (RT) inhibitor (NRTI)
analog of cytidine; and tenofovir disoproxil fumarate, an NRTI analog of adenosine
monophosphate, that is used to treat HIV infection. Upon oral administration, elvitegravir
inhibits the activity of integrase, an HIV-1 coded enzyme that is necessary for viral
replication. Inhibition of integrase prevents the integration of HIV-1 DNA into host
genomic DNA. Cobicistat inhibits CYP3A, thereby limiting the oxidative metabolism
of elvitegravir and increases its systemic exposure. Emtricitabine and tenofovir disoproxil
fumarate inhibit the activity of HIV RT by competing with natural deoxyribonucleosides
for incorporation into the growing viral DNA chain resulting in early chain termination.
This interferes with the generation of DNA copies of viral RNA, which is necessary
for the synthesis of new virions.;
Drug name : Stribild;
Origin ID : C157404;
UMLS CUI : C3837723;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
