Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate

Preferred Label : Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate;

NCIt synonyms : Efavirenz/Emtricitabine/Tenofovir; EFV/FTC/TDF;

NCIt definition : A fixed combination of efavirenz, a non-nucleoside reverse transcriptase (RT) inhibitor (NNRTI); emtricitabine, a nucleoside RT inhibitor (NRTI) analog of cytidine; and tenofovir disoproxil fumarate, an NRTI analog of adenosine monophosphate, that is used to treat human immunodeficiency virus (HIV) infection. Upon oral administration, efavirenz, emtricitabine, and tenofovir disoproxil fumarate inhibit the activity of HIV RT by competing with natural deoxyribonucleosides for incorporation into the growing viral DNA chain resulting in early chain termination. This interferes with the generation of DNA copies of viral RNA, which is necessary for the synthesis of new virions.;

Drug name : Atripla;

Details

Origin ID

C157403;

UMLS CUI

C2928676;

Currated CISMeF NLP mapping
- Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination [MeSH Descriptor]
- efavirenz, emtricitabine, tenofovir disoproxil fumarate drug combination [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to BTNT
- emtricitabine, tenofovir disoproxil and efavirenz [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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