Preferred Label : TCR alpha/beta/CD19-depleted Allogeneic Hematopoietic Progenitor Cells;
NCIt synonyms : TCR alpha/beta /CD19 Depleted HPCs; TCR alpha/beta /CD19 Depleted Hematopoietic Progenitor Cells; TCRab-/CD19-depleted Hematopoietic Progenitor Cells; Allogeneic TCRab/CD19-depleted Hematopoietic Stem Cells; TCRab /CD19 -depleted Haploidentical Donor HPCs; Allogeneic alpha, beta TCR/CD19-depleted HPCs; TCR alpha/beta/CD19-depleted HPCs; TCRab-/CD19-depleted Allogeneic Hematopoietic Progenitor Cells;
NCIt definition : A preparation of hematopoietic progenitor cells (HPCs) from a haploidentical donor
that have been depleted of T-cell receptor (TCR) alpha and beta (TCRa/b ) as well
as CD19-positive (CD19 ) cells, that can potentially be used for immune reconstitution
purposes. The TCR alpha/beta/CD19-depleted HPCs contain high amounts of natural killer
(NK) cells, gamma/delta T-cells, CD34 stem cells, monocytes, and dendritic cells
(DCs), while devoid of alpha/beta T-cells and CD19-positive B-cells. The TCR alpha/beta/CD19-depleted
HPCs are used for allogeneic hematopoietic cell transplantation (HCT) and may allow
for rapid and sustained engraftment, rapid immune reconstitution, and may prevent
or reduce graft-versus-host disease (GvHD).;
NCI Metathesaurus CUI : CL936944;
Origin ID : C157370;
UMLS CUI : C4761323;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
