Preferred Label : CD45RA-depleted Donor T-lymphocytes;
NCIt synonyms : CD45RA-depleted Allogeneic T-cells; CD45RA-depleted Allogeneic T-lymphocytes; CD45RA-depleted Donor T-cells; Donor CD45RA-depleted (memory) T-cells;
NCIt definition : A preparation of donor lymphocytes that have been depleted of CD45RA-positive cells,
that can potentially be used for immune reconstitution purposes. CD45RA depletion
results in a cellular product that contains a high amount of memory T-cells (Tm).
Upon infusion of the allogeneic CD45RA-depleted T-lymphocytes after a hematopoietic
cell transplantation (HCT), these cells provide Tm recovery and are able to prevent
viral infections. The depletion of the CD45RA-positive cells reduces the risk of graft-versus-host
disease (GvHD) upon infusion. CD45RA is expressed on naive T-cells, whereas Tm cells
are CD45RA-negative. Naive T-cells have the potential to induce GvHD.;
NCI Metathesaurus CUI : CL936943;
Origin ID : C157369;
UMLS CUI : C4763574;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
