Preferred Label : Allogeneic HAdV Antigen-specific T-lymphocytes;
NCIt synonyms : Allogeneic HAdV Antigen-specific T-cells; Allogeneic HAdV Antigen-selected T-cells; Allogeneic HAdV Antigen-selected T-lymphocytes; Allogeneic Human Adenovirus-specific T-lymphocytes;
NCIt definition : A population of allogeneic T-lymphocytes specifically reactive to human adenovirus
(HAdV) with potential antiviral activity. Allogeneic HAdV antigen-specific T-cells
are prepared via ex vivo stimulation of donor-derived peripheral blood mononuclear
cells (PBMCs) with HAdV hexon protein. T-cells that secrete interferon (IFN)-gamma
in response to HAdV antigen exposure are selected and expanded for administration.
Infusion of the HAdV antigen-specific T-lymphocytes into hematopoietic stem cell transplant
(HSCT) patients infected with HAdV may potentially reconstitute virus-specific responses,
thereby controlling HAdV infections.;
NCI Metathesaurus CUI : CL936967;
Origin ID : C157341;
UMLS CUI : C4763554;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
