Preferred Label : Allogeneic CMV Antigen-specific CD4 /CD8 T-lymphocytes;
NCIt synonyms : Allogeneic Cytomegalovirus-specific CD4 and CD8 T-lymphocytes; Allogeneic CMV-specific Antigen-selected T-cells; Allogeneic Cytomegalovirus-specific CD4 and CD8 T-cells;
NCIt definition : A population of allogeneic T-lymphocytes specifically reactive to cytomegalovirus
(CMV) with potential antiviral activity. Allogeneic CMV antigen-specific T-cells are
prepared via ex vivo stimulation of donor-derived peripheral blood mononuclear cells
(PBMCs) with major cytomegalovirus structural protein, pp65 (ppUL83). T-cells that
secrete interferon (IFN)-gamma in response to pp65 antigen exposure are selected and
expanded for administration. Administration of the CMV antigen-specific CD4 and CD8
T-lymphocytes into hematopoietic stem cell transplant (HSCT) or immunocompromised
patients infected with CMV may potentially reconstitute virus-specific responses,
thereby controlling CMV infections.;
NCI Metathesaurus CUI : CL936966;
Origin ID : C157340;
UMLS CUI : C4763553;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
