Preferred Label : Inodiftagene Vixteplasmid;
NCIt synonyms : Diphtheria-toxin-A-H19; dT-A-H19;
NCIt definition : A recombinant DNA plasmid carrying the gene for diphtheria toxin-A (dT-A) chain under
the regulation of the H19 promoter, with potential antineoplastic activity. Upon intravesical
administration, dT-A chain expression is triggered by the presence of H19 transcription
factors that are upregulated in tumor cells. The dT-A chain binds to nicotinamide
adenine dinucleotide (NAD) and inactivates the ADP-ribosylation of elongation factor
2 (EF2), resulting in the inhibition of protein synthesis and cell death leading to
tumor cell destruction. Inodiftagene Vixteplasmid does not carry the gene for the
diphtheria toxin-B (dT-B) chain, thereby preventing the transfer of the toxic dT-A
chain between cells. H19, a paternally imprinted, oncofetal gene, is highly expressed
in embryonic and certain malignant tissues, but minimally expressed in normal, adult
tissues.;
UNII : 98YK326XZ6;
CAS number : 2166100-08-7;
Molecule name : BC-819; BC 819;
NCI Metathesaurus CUI : CL937035;
Origin ID : C157333;
UMLS CUI : C4763548;
Semantic type(s)
- concept_is_in_subset
