Preferred Label : 4-[18F]Fluoroglutamic Acid;
NCIt synonyms : [18F] 4-L-fluoroglutamine (2S,4R); (2S)-2-Amino-4-[F-18]-fluoro Pentanedioic Acid; Fluorine F 18-BAY 85-8050; [F-18]BAY 85-8050;
NCIt related terms : BAY-85-8050;
NCIt definition : A radioconjugate composed of the radionuclide fluorine F 18 conjugated to L-glutamic
acid, with potential imaging activity upon positron emission tomography (PET). Upon
intravenous administration, the glutamic acid moiety of 4-[18F]fluoroglutamic acid
specifically binds to tumor cells and is preferentially taken up by tumor cells due
to the higher metabolic activity and enhanced glutaminolytic pathway in these cells
compared to normal, healthy cells. Upon internalization and PET, tumor cells can be
imaged and assessed. Tumor cells use the amino acid glutamine for nutritional purposes
necessary for energy production and growth; as tumor cells proliferate more rapidly
than normal healthy cells, glutamine uptake is higher in certain cancer cells.;
UNII : FB9L37AF2L;
CAS number : 1022082-18-3;
Molecule name : BAY 85-8050;
NCI Metathesaurus CUI : CL937021;
Origin ID : C157280;
UMLS CUI : C4763522;
Semantic type(s)
- concept_is_in_subset
