" /> Mirzotamab Clezutoclax - CISMeF





Preferred Label : Mirzotamab Clezutoclax;

NCIt synonyms : ADC ABBV-155; Antibody-drug Conjugate ABBV-155;

NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) conjugated, via a solubilizing linker, to a B-cell lymphoma extra long (Bcl-XL) inhibitor, with potential antineoplastic activity. Upon administration of mirzotamab clezutoclax, the anti-B7-H3 monoclonal antibody moiety targets and binds to B7-H3 expressed on tumor cells. Upon binding, internalization and linker cleavage, the Bcl-XL inhibitor targets, binds to and inhibits the activity of the pro-survival protein Bcl-XL. This restores apoptotic processes and inhibits the proliferation of B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It plays a key role in tumor growth and immune responses.;

UNII : TY49T0B03B;

CAS number : 2229859-12-3;

Molecule name : ABBV 155; ABBV-155;

NCI Metathesaurus CUI : CL937020;

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09/05/2025


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