Preferred Label : pDNA-encoding Emm55 Autologous Cancer Cell Vaccine IFx-Hu2.0;
NCIt synonyms : Plasmid DNA Vaccine Encoding S. pyogenes Emm55 Protein; pDNA Autologous Cancer Cell Vaccine IFx-Hu2.0; Autologous Cancer Cell-transfected with Plasmid DNA Encoding for Emm55 Streptococcal
Antigen IFx-Hu2.0; Plasmid DNA Autologous Cancer Vaccine IFx-Hu2.0;
NCIt definition : A whole cell cancer vaccine composed of irradiated autologous whole tumor cells that
are transfected, ex vivo, with a plasmid DNA encoding the highly immunogenic Streptococcus
pyogenes (S. pyogenes) bacterial antigen Emm55, with potential immunostimulating and
antineoplastic activities. Upon intralesional administration of IFx-Hu2.0, the tumor
cells expressing the Emm55 bacterial antigen on their cell surface are taken up and
processed by antigen-presenting cells (APCs), thereby presenting both the Emm55 and
the patient-specific tumor-associated antigens (TAAs) to the immune system. This activates
the immune system to elicit a tumor antigen-specific cytotoxic T-lymphocyte (CTL)-mediated
immune response against the tumor cells expressing the TAAs.;
Drug name : ImmuneFx;
Molecule name : IFx-Hu2.0;
NCI Metathesaurus CUI : CL936865;
Origin ID : C157262;
UMLS CUI : C4763518;
Semantic type(s)
- concept_is_in_subset
