Preferred Label : Phosphorylated-STAT3 Y705;
NCIt synonyms : STAT3 Phosphorylated on Tyr705; Phosphorylated-Signal Transducer and Activator of Transcription 3 Y705; STAT3 pY705; Phospho-STAT3 Y705; pY-STAT3; STAT3 (pY705); STAT3 (Phospho-Tyr705); Phosphorylated STAT3 Y705;
NCIt definition : A post-translationally modified form of signal transducer and activator of transcription
3 (STAT3) where the tyrosine (Y; Tyr) at residue 705 is phosphorylated. Janus kinase
(JAK)-mediated phosphorylation of Y705 activates STAT3 and promotes the formation
of STAT3-containing dimers, which translocate into the nucleus and induce STAT3-dependent
gene expression.;
NCIt note : Additional phosphorylation of signal transducer and activator of transcription 3 (STAT3)
the serine (S; Ser) at residue 727, appears to stabilize DNA-binding STAT3 homodimers
and promotes maximal transcriptional activity. (UniProt);
NCI Metathesaurus CUI : CL936807;
Origin ID : C157132;
UMLS CUI : C4763431;
Semantic type(s)
- concept_is_in_subset
- related_to_genetic_biomarker
