Acetaminophen-Cysteine Protein Adduct

Preferred Label : Acetaminophen-Cysteine Protein Adduct;

NCIt synonyms : APAP-CYS; Acetaminophen-Cysteine; Acetaminophen Protein Adduct; PPA; Paracetamol-Cysteine; Paracetamol Protein Adduct;

NCIt definition : A modified protein, usually glutathione, where oxidized acetaminophen is bound to the sulfhydryl group of cysteine residues. The presence of acetaminophen-cysteine or its proteolyzed product 3-para cysteinyl acetaminophen in a sample is a specific biomarker for acetaminophen exposure and increased concentrations of these adducts may be associated with acetaminophen toxicity.;

NCI Metathesaurus CUI : CL936823;

Details

Origin ID

C157112;

UMLS CUI

C4761317;

Automatic exact mappings (from CISMeF team)
- Frontotemporal dementia 2 [OMIM Phenotype]
- Primary progressive aphasia [ORDO Disease]
- african swine fever [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Acetaminophen-cysteine adduct [LOINC component]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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