Preferred Label : L-lysine/L-arginine-containing Amino Acid;
NCIt synonyms : Intravenous L-lysine/L-arginine-containing Amino Acid Solution; L-lysine/L-arginine AA Solution; Amino Acid Solution-containing L-lysine and L-arginine; Amino Acid Renal Protectant Solution; Lysine/Arginine Amino Acid Solution; Lysine-Arginine Amino Acid Solution;
NCIt definition : An intravenous (IV) amino acid (AA) solution containing the cationic amino acids L-lysine
and L-arginine, with radioprotective activity. Upon IV administration of the AA solution,
L-lysine and L-arginine are specifically taken up by the kidneys. This protects the
kidneys from toxicity by certain co-administered radio-labeled peptides as they compete
with radio-labeled peptides for renal uptake. This reduces uptake of the radio-labeled
peptides by the kidneys and decreases their renal retention. It also increases the
target-to-kidney ratio of the radio-labeled peptides, thereby reducing radiation exposure
to the kidneys and preventing nephrotoxicity.;
Molecule name : Radioprotective Amino Acid Solution;
NCI Metathesaurus CUI : CL936065;
Origin ID : C157025;
UMLS CUI : C4745224;
Semantic type(s)
- concept_is_in_subset
