Preferred Label : Carbon C 11-osimertinib;
NCIt synonyms : [11C] Osimertinib; 11C-osimertinib; [11C]AZD9291;
NCIt definition : A radioconjugate composed of osimertinib, a third-generation, orally available, irreversible,
mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, labeled with
the positron-emitting isotope carbon C 11, with potential use in imaging via positron
emission tomography (PET). Upon intravenous administration of carbon C 11 osimertinib,
the osimertinib targets and binds to mutant forms of EGFR on tumor cells. Upon PET
imaging, this radioligand may allow for the assessment of EGFR mutant-expressing tumor
cells. This also allows assessment of osimetinib's pharmacokinetic profile and affinity
of EGFR mutant-positive cancer cells and may identify patients who may respond well
to osimertinib.;
NCI Metathesaurus CUI : CL935893;
Origin ID : C156742;
UMLS CUI : C4745033;
Semantic type(s)
- concept_is_in_subset
