Preferred Label : Zirconium Zr 89-DFO-cRGDY PEG-Cy5-C' Dots;
NCIt synonyms : 89Zr-DFO-cRGDY-PEG-Cy5-C' Dot Particles; 89Zr-DFO-cRGDY-PEG-Cy5-C' Dot Nanoparticles; Zr 89-DFO-cRGDY PEG-Cy5-C' Dots; 89Zr-DFO-cRGDY-PEG-Cy5-C' Dots;
NCIt definition : A radioconjugate composed of a tumor-selective fluorescent imaging agent containing
silica-based nanoparticles labeled with a near-infrared (NIR) fluorophore, cyanine
5 (Cy5), and surrounded by polyethylene glycol (PEG) chains attached to cyclic arginine-glycine-aspartic
acid-tyrosine) (cyclo-(Arg-Gly-Asp-Tyr; cRGDY) peptides (C' dots; Cornell prime dots;
cRGDY-PEG-C' dots), and linked, via the chelator desferrioxamine (DFO), to the radioisotope
zirconium Zr 89 (Zr89), with potential diagnostic properties upon positron emission
tomography (PET) imaging. Upon intradermal administration of the zirconium Zr 89 cRGDY
PEG-Cy5-C' dots, the cRGDY moiety selectively binds to alphaVbeta3 integrin expressed
on tumor cells. Upon binding, the radioisotope moiety may be detected using PET, thereby
allowing the imaging and quantification of integrin-expressing tumor cells as well
as the visualization of the distribution, uptake and removal within tumor tissues.
The fluorescence imaging agent is used to visualize alphaVbeta3-expressing tumor cells
and assess the degree of both tumor metastasis and sentinel lymph node (SLN) trafficking.
Integrins are transmembrane glycoproteins upregulated on proliferating tumor vessel
endothelial cells and various cancer cells; their overexpression has been associated
with neovascularization, differentiation, proliferation of tumor cells, metastasis
and an overall poor prognosis.;
NCI Metathesaurus CUI : CL935906;
Origin ID : C156739;
UMLS CUI : C4745030;
Semantic type(s)
- concept_is_in_subset
