Preferred Label : Nurulimab;
NCIt synonyms : Anti-CTLA-4 Monoclonal Antibody BCD-145;
NCIt definition : A monoclonal antibody directed against the human T-cell-expressed receptor cytotoxic
T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint
inhibitory and antineoplastic activities. Upon administration, nurulimab targets and
binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation
of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune
response against cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin
superfamily (IgSF), plays a key role in the downregulation of the immune system.;
UNII : 894KSI08XK;
CAS number : 2168561-20-2;
Molecule name : BCD-145; BCD 145;
NCI Metathesaurus CUI : CL935901;
Origin ID : C156734;
UMLS CUI : C5418259;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
