Preferred Label : EGFR Antisense DNA BB-401;
NCIt synonyms : Anti-EGFR ddRNAi BB-401; ddRNAi BB-401;
NCIt definition : A recombinant, plasmid DNA expression vector encoding a 39 nucleotide (nt) short hairpin
RNA (shRNA) specific for the epidermal growth factor receptor (EGFR), with potential
antineoplastic activity. Upon intratumoral administration, the EGFR antisense DNA
BB-401 is taken up by tumor cells and shRNA is transcribed. The shRNA is converted
into small interfering RNA (siRNA) via the RNA interference (RNAi) pathway. The siRNA
targets and binds to EGFR RNA expressed by tumor cells. This blocks EGFR mRNA translation
and prevents EGFR protein expression.;
Molecule name : BB-401; BB 401;
NCI Metathesaurus CUI : CL935856;
Origin ID : C156732;
UMLS CUI : C4745024;
Semantic type(s)
- concept_is_in_subset
