Preferred Label : Sodium-Potassium Adenosine Triphosphatase Inhibitor RX108;
NCIt synonyms : Sodium-Potassium Pump Inhibitor RX10; Na /K -ATPase Inhibitor RX108;
NCIt definition : A small-molecule, inhibitor of sodium-potassium adenosine triphosphatase (Na /K -ATPase)
with potential antineoplastic activity. Upon administration, RX108 inhibits the activity
of the Na /K -ATPase, which prevents the activation of various signal transduction
pathways that play a key role in tumor proliferation. This may lead to cell-cycle
arrest, apoptosis, and autophagic cell death. Na /K -ATPase is overexpressed in certain
tumor types and may serve as a scaffold for the assembly of multiple-protein signaling
complexes that regulate cell proliferation and motility. In normal, healthy cells,
the Na /K -ATPase controls transportation of Na and K across the cell membrane and
is essential for electrochemical gradient maintenance, osmotic balance, and cellular
pH.;
Molecule name : RX-108; RX 108;
NCI Metathesaurus CUI : CL935853;
Origin ID : C156728;
UMLS CUI : C4745021;
Semantic type(s)
- concept_is_in_subset
