Para-toluenesulfonamide

Preferred Label : Para-toluenesulfonamide;

NCIt synonyms : PTS; PTS-100;

NCIt related terms : P-TOLUENESULFONAMIDE;

NCIt definition : A low-molecular-weight organic compound with potential antineoplastic activity. Upon intra-tumoral injection, para-toluenesulfonamide increases lysosomal membrane permeabilization (LMP) and the release of cathepsin B. Cytosolic cathepsin B released from lysosomes cleaves and activates proapoptotic B-cell lymphoma 2 (Bcl-2) family member BH3 interacting-domain death agonist (Bid) and poly [ADP-ribose] polymerase 1 (PARP-1), which may induce tumor cell death.;

UNII : I8266RI90M;

Molecule name : PTS 100; PTS100;

NCI Metathesaurus CUI : CL935868;

Details

Origin ID

C156702;

UMLS CUI

C0048719;

Automatic exact mappings (from CISMeF team)
- 4-toluenesulfonamide [MeSH Supplementary Concept]
- 6-pyruvoyl-tetrahydropterin synthase [OMIM gene]
- 6-pyruvoyltetrahydropterin synthase [ORDO Gene]
- multiple chemical sensitivity [MeSH Descriptor]
Semantic type(s)
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- 4-toluenesulfonamide [MeSH concept]
- 4-toluenesulfonamide [MeSH Supplementary Concept]
- toluene-4-sulphonamide [Substance BNPC]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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