NCIt definition : A synthetic compound containing the bisphosphonate etidronate (hydroxyethylidene diphosphonate,
HEDP) labeled with rhenium Re188, a beta-emitting radioisotope with potential antineoplastic
activity. Upon administration, Re-188 etidronate binds to hydroxyapatite in bone,
delivering a cytotoxic dose of beta radiation to primary and metastatic bone tumors.
The beta-radiation may provide localized anti-tumor radiotoxicity while sparing extramedullary
bone marrow tissues.;