Preferred Label : SHP-1 Agonist SC-43;
NCIt synonyms : SC-43 Oral Solution; 1-[4-Chloro-3(trifluoromethyl)phenyl-3-[3-(4-cyanophenoxy)] Urea;
NCIt related terms : SC-43;
NCIt definition : An orally available, small molecule agonist of Src homology region 2 domain-containing
phosphatase-1 (SHP-1; tyrosine-protein phosphatase non-receptor type 6; PTPN6) with
potential antineoplastic activity. Upon administration, SHP-1 agonist SC-43 enhances
SHP-1 activity by impairing the association between the N-terminal Src homology 2
(N-SH2) domain and the protein tyrosine phosphatase (PTP) domain of SHP-1, triggering
a conformational change of SHP-1 and relieving its autoinhibition. Activation of SHP-1
represses signal transducer and activator of transcription 3 (STAT3) signaling by
inhibiting constitutive and interleukin-6 (IL-6)-induced STAT3 phosphorylation. The
STAT3 pathway is overly active in many cancer types and is implicated in cancer stem
cell-mediated growth, recurrence, stemness, and resistance to conventional chemotherapies.;
UNII : OT4AQX5MLU;
CAS number : 1400989-25-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1400989-25-4
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G-SRS /a ;
Molecule name : SC 43; SC-43;
NCI Metathesaurus CUI : CL935710;
Origin ID : C156695;
UMLS CUI : C4744995;
Semantic type(s)
- concept_is_in_subset
