" /> Bapotulimab - CISMeF





Preferred Label : Bapotulimab;

NCIt synonyms : ILDR2 Function-blocking Antibody BAY1905254; Anti-immunoglobulin-like Domain Containing Receptor 2 MoAb BAY1905254; Immune Checkpoint Inhibitor BAY1905254; Anti-ILDR2 Inhibitor BAY1905254; Anti-ILDR2 Monoclonal Antibody BAY 1905254;

NCIt definition : A mouse/human cross-reactive immunoglobulin G2 (IgG2) monoclonal antibody against the immune checkpoint immunoglobulin-like domain containing receptor 2 (ILDR2; Chromosome 1 Open Reading Frame 32; C1orf32), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, bapotulimab targets, binds to and inhibits ILDR2, thereby blocking the immunosuppressive activity of ILDR2. This prevents ILDR2-mediated inhibition of T-cell activities and induces a cytotoxic T-lymphocyte (CTL) response against tumor cells. ILDR2, a type I transmembrane protein belonging to the B7 family of immunomodulatory receptors, negatively regulates T-cell responses.;

UNII : I92BM16NTD;

CAS number : 2359413-58-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2359413-58-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BAY-1905254; BAY 1905254;

NCI Metathesaurus CUI : CL935671;

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10/05/2024


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