Preferred Label : Pharmacological Ascorbate;
NCIt synonyms : High Dose Ascorbic Acid; IV Ascorbate; Ascorbate Injection; High-Dose Vitamin C; HD Ascorbate; Intravenous High Dose Ascorbate; Ascorbic Acid Injection; High-dose Ascorbate; Intravenous Ascorbate; HD Vitamin C; HD P-AscH-; High-dose Ascorbic Acid; High-Dose Parenteral Ascorbate;
NCIt definition : A high dose (HD) of ascorbic acid, a pro-oxidant agent, with potential antineoplastic
and radio-chemo-sensitizing activities. Upon intravenous (IV) administration, pharmacological
ascorbate is able to generate reactive oxygen species (ROS) by donating an electron
to oxygen (O2) and forming hydrogen peroxide (H2O2), thereby causing oxidative stress
and overwhelming the cell's anti-oxidant defense mechanisms. This induces DNA double-stranded
breaks (DSBs) and cell death. Tumor cells are highly susceptible to ascorbate-mediated
oxidative stress and cytotoxicity while normal, healthy cells are mostly unaffected.
This induces the cell death of susceptible tumor cells and decreases tumor cell growth.
Higher plasma ascorbate concentrations are achieved upon higher intravenous doses
of ascorbate; oral administration of ascorbate is limited and uptake does not increase
after a certain amount is administered. Only IV ascorbate produces plasma concentrations
high enough to induce ascorbate-mediated cytotoxicity to susceptible tumor cells.
In addition, HD parenteral ascorbate enhances radio- and chemo-sensitivity of susceptible
cancer cells.;
NCI Metathesaurus CUI : CL563189;
Origin ID : C156461;
UMLS CUI : C4744839;
Semantic type(s)
- concept_is_in_subset
